Published Research

Scientific research is extremely important in improving the treatment and curability of PMP, appendix cancer, and related peritoneal surface malignancies. Following are some of the pertinent research studies that have been published from 2004 to present.

* Research marked with an asterisk was partially or wholly funded by a PMPRF Research Grant.

Studies Published - 2016

Adverse Events Postoperatively Had No Impact on Long-Term Survival of Patients Treated with Cytoreductive Surgery with Heated Intraperitoneal Chemotherapy for Appendiceal Cancer with Peritoneal Metastases.
Ihemelandu C, Mavros MN, Sugarbaker P

Precutting EMR for cecal tumors extending to the appendiceal orifice .
Imai K, Hotta K, Kakushima N, Ono H

Lymph Node Metastasis Predicts Disease Recurrence in a Single-Center Experience of 70 Stages 1-3 Appendix Cancers: A Retrospective Review .
Nash GM, Smith JD, Tang L, Weiser MR, Temple LK, O'Reilly E, Saltz LB, Guillem JG, Paty PB.

Long-Term Survival is not Impaired After the Complete Resection of Neuroendocrine Tumors of the Appendix..
Steffen T, Ebinger SM, Warschkow R, Lüthi C, Schmied BM, Clerici T.

Thigh abscess as an extension of psoas abscess: the first manifestation of perforated appendiceal adenocarcinoma: case report .
Petrovic I, Pecin I, Prutki M, Augustin G, Nedic A, Gojevic A, Potocki K, Reiner Z

Is the Combination of Distal Pancreatectomy and Cytoreductive Surgery With HIPEC Reasonable?: Results of an International Multicenter Study .
Schwarz L, Votanopoulos K, Morris D, Yonemura Y, Deraco M, Piso P, Moran B, Levine EA, Tuech JJ Z

Curative Surgical Resection as a Component of Multimodality Therapy for Peritoneal Metastases from Goblet Cell Carcinoids .
Radomski M, Pai RK, Shuai Y, Ramalingam L, Jones H, Holtzman MP, Ahrendt SA, Pingpank JF, Zeh HJ, Bartlett DL, Choudry HA

Appendiceal mixed adenoneuroendocrine carcinomas, a rare entity that can present as a Krukenberg tumor: case report and review of the literature .
Romeo M, Quer A, Tarrats A, Molina C, Radua J, Manzano JL

Pseudomyxoma Peritonei of Extra-Appendiceal Origin: A Comparative Study .
Baratti D, Kusamura S, Milione M, Pietrantonio F, Caporale M, Guaglio M, Deraco M

5-Aminolevulinic Acid Fluorescence in Detection of Peritoneal Metastases .
Yonemura Y, Canbay E, Ishibashi H, Nishino E, Endou Y, Sako S, Ogura S

Improved Survival with Anti-VEGF Therapy in the Treatment of Unresectable Appendiceal Epithelial Neoplasms .
Choe JH1, Overman MJ, Fournier KF, Royal RE, Ohinata A, Rafeeq S, Beaty K, Phillips JK, Wolff RA, Mansfield PF, Eng C

The results of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in 1200 patients with peritoneal malignancy .
Moran B, Cecil T, Chandrakumaran K, Arnold S, Mohamed F, Venkatasubramaniam A

Cytoreduction and hyperthermic intraperitoneal chemotherapy: The learning curve reassessed .
Kuijpers AM, Hauptmann M, Aalbers AG, Nienhuijs SW, de Hingh IH, Wiezer MJ, van Ramshorst B, van Ginkel RJ, Havenga K, Verwaal VJ

Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in 1000 patients with perforated appendiceal epithelial tumours .
Ansari N, Chandrakumaran K, Dayal S, Mohamed F, Cecil TD, Moran BJ

Strategies for Preventing Pseudomyxoma Peritonei After Resection of a Mucinous Neoplasm of the Appendix .
Honoré C, Caruso F, Dartigues P, Benhaim L, Chirica M, Goéré D, Elias D

Prophylactic hyperthermic intraperitoneal chemotherapy in patients with epithelial appendiceal neoplasms .
Tuvin D, Berger Y, Aycart SN, Shtilbans T, Hiotis S, Labow DM, Sarpel U

Impact of Mucinous Histology on the Prognosis of Stage I-III Adenocarcinomas of the Appendix: a Population-Based, Propensity Score-Matched Analysis.
Widmann B, Warschkow R, Schmied B, Marti L, Steffen T 

Diagnosis and Treatment of Mucinous Appendiceal Neoplasm Presented as Acute Appendicitis.
Kehagias I, Zygomalas A, Markopoulos G, Papandreou T, Kraniotis P

Pathology of Mucinous Appendiceal Tumors and Pseudomyxoma Peritonei Tumours..
Ramaswamy V

The Initial Indian Experience with Cytoreductive Surgery and HIPEC in the Treatment of Peritoneal Metastases .
Bhatt A, Mehta S, Seshadri RA, Sethna K, Zaveri S, Rajan F, Mahajan V, Singh S, Raj EH, Sugarbaker PH

Safety considerations for Health care Workers involved in Cytoreductive Surgery and Perioperative chemotherapy..
Bhatt A, Mittal S, Gopinath KS

Intensive Care Management of Patient After Cytoreductive Surgery and HIPEC - A Concise Review.
Padmakumar AV

Diagnostic Laparoscopy in the Pre-operative Assessment of Patients Undergoing Cytoreductive Surgery and HIPEC for Peritoneal Surface Malignancies..
Seshadri RA, Hemanth Raj E

Complications of Cytoreductive Surgery and HIPEC in the Treatment of Peritoneal Metastases.
Mehta SS, Gelli M, Agarwal D, Goéré D

Intrathoracic Chemoperfusion Decreases Recurrences in Patients with Full-Thickness Diaphragm Involvement with Mucinous Appendiceal Adenocarcinoma.
Grotz TE, Mansfield PF, Royal RE, Mann GN, Rafeeq S, Beaty KA, Overman MJ, Fournier KF.

Cytoreductive Surgery Combined with Hyperthermic Intraperitoneal Chemotherapy with Oxaliplatin Increases the Risk of Postoperative Hemorrhagic Complications: Analysis of Predictive Factors .
Charrier T, Passot G, Peron J, Maurice C, Gocevska S, Quénet F, Eveno C, Pocard M, Goere D, Elias D, Ortega-Deballon P, Vaudoyer D, Cotte E, Glehen O.

Repeated cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) in patients with recurrent peritoneal carcinomatosis .
Vassos N, Förtsch T, Aladashvili A, Hohenberger W, Croner RS.

FDG-PET/ceCT is useful to predict recurrence of Pseudomyxoma peritonei..
Julien D, Francesco G, Pascal R, Naoual B, Guillaume P, Sylvie I, Olivier G, Andrea S.

Retrospective analysis on the safety of 5,759 times of bedside hyperthermic intra-peritoneal or intra-pleural chemotherapy (HIPEC).
Liu L, Zhang N, Min J, Su H, Wang H, Chen D, Sun L, Zhang H, Li W, Zhang H.

Cytoreductive surgery and intraperitoneal chemotherapy: an evidence-based review-past, present and future.
Dehal A, Smith JJ, Nash GM.

Preoperative and surveillance MR imaging of patients undergoing cytoreductive surgery and heated intraperitoneal chemotherapy.
Low RN.

Surgical technology and pharmacology of hyperthermic perioperative chemotherapy.
Sugarbaker PH, Van der Speeten K.

Peritoneal dissemination from high-grade appendiceal cancer treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC).
Cummins KA, Russell GB, Votanopoulos KI, Shen P, Stewart JH, Levine EA

Impact of surgical volume of centers on post-operative outcomes from cytoreductive surgery and hyperthermic intra-peritoneal chemoperfusion.
Rajeev R, Klooster B, Turaga KK

Effect of a concomitant urologic procedure on outcomes following cytoreductive surgery with hyperthermic intraperitoneal chemotherapy.
Lyon TD, Turner Ii RM, Nikonow TN, Wang L, Uy J, Ramalingam L, Holtzman MP, Pingpank JF, Bartlett DL, Davies BJ

Does early post-operative intraperitoneal chemotherapy (EPIC) for patients treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) make a difference? ..
Tan GH1, Ong WS1, Chia CS1, Tham CK1, Soo KC1, Teo MC1

Laparoscopic HIPEC: A bridge between open and closed-techniques.
Lotti M, Capponi MG, Piazzalunga D, Poiasina E, Pisano M, Manfredi R, Ansaloni L.

Pseudomyxoma Peritonei: Symptom Control and Objective Radiological Response after Treatment with Lanreotide Autogel .
Zafra GM, Luque P.

Evaluation of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in a community setting: A cost-utility analysis of a hospital's initial experience and reflections on the health care system .
Naffouje SA, O'Donoghue C, Salti GI

Patients with Peritoneal Carcinomatosis from Gastric Cancer Treated with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy: Is Cure a Possibility .
Chia CS,You B, Decullier E, Vaudoyer D,Lorimier G, Abboud K, Bereder JM, Arvieux C, Boschetti G,Glehen O,BIG RENAPE Group.

Studies Published - 2015

Comparison of long-term oncological outcomes of appendiceal cancer and colon cancer: A multicenter retrospective study .
Son IT, Ahn S, Park KJ, Oh JH, Jeong SY, Park HC, Heo SC, Youk EG, Park JT, Ihn MH, Oh HK, Kim DW, Lee KH, Kang SB; Seoul Colorectal Group (SECOG)

The 7th Edition of the AJCC Staging Classification Correlates with Biologic Behavior of Mucinous Appendiceal Tumor with Peritoneal Metastases Treated with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (CRS/HIPEC).
Milovanov V, Sardi A, Studeman K, Nieroda C, Sittig M, Gushchin V.

Life after hyperthermic intraperitoneal chemotherapy; measuring quality of life and performance status after cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy.
Ford J, Hanna M, Boston A, Berri R

Prognostic Molecular Subtypes of Low-Grade Cancer of the Appendix.
Levine EA, Votanopoulos KI, Qasem SA, Philip J, Cummins KA, Chou JW, Ruiz J, D'Agostino R, Shen P, Miller LD.

Cytoreductive Surgery Plus Hyperthermic Intraperitoneal Chemotherapy for Pseudomyxoma Peritonei Arising from Urachus..
Liu Y, Ishibashi H, Hirano M, Takeshita K, Mizumoto A, Ichinose M, Nishino E, Kashu I, Yamamoto Y, Sugarbaker PH, Yonemura Y.

A Novel Tool for Predicting Major Complications After Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy.
Baumgartner JM, Kwong TG, Ma GL, Messer K, Kelly KJ, Lowy

Appendicular Mucocele: Possibilities and Limits of Laparoscopy. Brief Series and Review of the Literature.
Tărcoveanu E, Vasilescu A, Hee RV, Moldovanu R, Ursulescu C, Ciobanu D, Bradea C;

BEV-IP: Perioperative chemotherapy with bevacizumab in patients undergoing cytoreduction and intraperitoneal chemoperfusion for colorectal carcinomatosis.
Willaert W, Van Der Speeten K, Liberale G, Ceelen W.

Laparoscopic evacuation of mucinous ascites for palliation of pseudomyxoma peritonei
Kelly KJ,Baumgartner JM,Lowy AM.

Appendiceal mixed adenoneuroendocrine carcinomas, a rare entity that can present as a Krukenberg tumor: case report and review of the literature.
Romeo M, Quer A, Tarrats A, Molina C, Radua J, Manzano JL.

Clinicopathologic and Prognostic Features in Patients with Peritoneal Metastasis from Mucinous Adenocarcinoma, Adenocarcinoma with Signet Ring Cells, and Adenocarcinoid of the Appendix Treated with Cytoreductive Surgery and Perioperative Intraperitoneal Chemotherapy.
Ihemelandu C, Sugarbaker PH.

Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Pseudomyxoma Peritonei and Appendix Tumours.
Lansom J, Alzahrani N, Liauw W, Morris DL.

Recommendations in the management of epithelial appendiceal neoplasms and peritoneal dissemination from mucinous tumours (pseudomyxoma peritonei).
Barrios P, Losa F, Gonzalez-Moreno S, Rojo A, Gómez-Portilla A, Bretcha-Boix P, Ramos I, Torres-Melero J, Salazar R, Benavides M, Massuti T, Aranda E.

A Consensus for Classification and Pathologic Reporting of Pseudomyxoma Peritonei and Associated Appendiceal Neoplasia: The Results of the Peritoneal Surface Oncology Group International (PSOGI) Modified Delphi Process.
Carr NJ, Cecil TD, Mohamed F, Sobin LH, Sugarbaker PH, González-Moreno S, Taflampas P, Chapman S, Moran BJ.

Conditional Survival After Cytoreductive Surgery with Heated Intraperitoneal Chemotherapy for Low- and High-Grade Appendiceal Primaries
Mogal HD, Levine EA, Russell G, Shen P, Stewart JH, Votanopoulos KI

Extensive surgical history prior to cytoreductive surgery and hyperthermic intraperitoneal chemotherapy is associated with poor survival outcomes in patients with peritoneal mucinous carcinomatosis of appendiceal origin
Milovanov V, Sardi A, Aydin N, Nieroda C, Sittig M, Nunez M, Gushchin V

Hyperthermic Intraperitoneal Chemotherapy Following Cytoreductive Surgery Improves Outcome in Patients With Primary Appendiceal Mucinous Adenocarcinoma: A Pooled Analysis From Three Tertiary Care Centers
Shaib WL, Martin LK, Choi M, Chen Z, Krishna K, Kim S, Brutcher E, Staley C 3rd, Maithel SK, Philip P, Abdel-Misih S, Bekaii-Saab TS, El-Rayes BF

Goblet cell appendiceal tumors--management dilemmas and long-term outcomes
Rossi RE, Luong TV, Caplin ME, Thirlwell C, Meyer T, Garcia-Hernandez J, Baneke A, Conte D, Toumpanakis C.

A comparative analysis of postoperative pancreatic fistulas after surgery with and without hyperthermic intraperitoneal chemoperfusion
Downs-Canner S, Ding Y, Magge DR, Jones H, Ramalingam L, Zureikat A, Holtzman M, Ahrendt S, Pingpank J, Zeh HJ, Bartlett DL, Choudry HA.

Comparison of MRI and CT for predicting the Peritoneal Cancer Index (PCI) preoperatively in patients being considered for cytoreductive surgical procedures
Low RN, Barone RM, Lucero J

Hyperthermic intraperitoneal chemotherapy + early postoperative intraperitoneal chemotherapy versus hyperthermic intraperitoneal chemotherapy alone: assessment of survival outcomes for colorectal and high-grade appendiceal peritoneal carcinomatosis
Lam JY, McConnell YJ, Rivard JD, Temple WJ, Mack LA

* Targeting hypoxia-mediated mucin 2 production as a therapeutic strategy for mucinous tumors.
Dilly AK, Lee YJ, Zeh HJ, Guo ZS, Bartlett DL, Choudry HA

* Mitogen-activated protein kinase inhibition reduces mucin 2 production and mucinous tumor growth.
Dilly AK, Song X, Zeh HJ, Guo ZS, Lee YJ, Bartlett DL, Choudry HA

* Global gene expression in pseudomyxoma peritonei, with parallel development of two immortalized cell lines
Darren L. Roberts, Sarah T. O’Dwyer, Peter L. Stern, Andrew G. Renehan

In vivo assessment of growth-inhibitory and mucin-depleting effects of bromelain and N-acetylcysteine in peritoneal carcinomatosis models
Amini A, Masoumi-Moghaddam S, Morris DL

Systemic chemotherapy (SC) before cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) in patients with peritoneal mucinous carcinomatosis of appendiceal origin (PMCA)
Milovanov V, Sardi A, Ledakis P, Aydin N, Nieroda C, Sittig M, Nunez M, Gushchin V

The Rise in Appendiceal Cancer Incidence: 2000-2009
Marmor S, Portschy PR, Tuttle TM, Virnig BA

A rare cause of ascites: pseudomyxoma peritonei and a review of the literature
Abhishek Chauhan, Nishant Patodi, and Monz Ahmed

Goblet cell carcinoids: characteristics of a Danish cohort of 83 patients.
Olsen I, Holt N, Langer SW, Hasselby JP, Grønbæk H, Hillingsø J, Mahmoud M, Ladekarl M, Iversen LH, Kjær A, Federspiel BH, Knigge U.

A Simplified Preoperative Assessment Predicts Complete Cytoreduction and Outcomes in Patients with Low-Grade Mucinous Adenocarcinoma of the Appendix
Dineen SP, Royal RE, Hughes MS, Sagebiel T, Bhosale P, Overman M, Matamoros A, Mansfield PF, Fournier KF

Elevated tumour markers are normalized in most patients with pseudomyxoma peritonei one week after complete tumour removal
Di Fabio F, Aston W, Mohamed F, Chandrakumaran K, Cecil T, Moran B

Mucinous epithelial neoplasms of the appendix and pseudomyxoma peritonei
Misdraji J

Studies Published - 2014

Cytological findings of appendiceal mixed adenoneuroendocrine carcinoma in pleural effusion: Morphological changes evident after metastasis..
Tonooka A, Oda K, Hayashi M, Sakazume K, Tanaka H, Kaburaki KH, Uekusa T.

Institutional Learning Curve of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemoperfusion for Peritoneal Malignancies
Polanco PM, Ding Y, Knox JM, Ramalingam L, Jones H, Hogg ME, Zureikat AH, Holtzman MP, Pingpank J, Ahrendt S, Zeh HJ, Bartlett DL, Choudry HA

Multicentre study of the learning curve and surgical performance of cytoreductive surgery with intraperitoneal chemotherapy for pseudomyxoma peritonei
Kusamura S, Moran BJ, Sugarbaker PH, Levine EA, Elias D, Baratti D, Morris DL, Sardi A, Glehen O, Deraco M; Peritoneal Surface Oncology Group International (PSOGI)

The RENAPE network: towards a new healthcare organization for the treatment of rare tumors of the peritoneum. Description of the network and role of the pathologists
Villeneuve L, Isaac S, Glehen O, Capovilla M, Chevallier A, Croce S, Dartigues P, Fontaine J, Kaci R, Lang-Averous G, Laverriere MH, Leroux-Broussier A, Mery E, Poizat F, Valmary-Degano S, Verriele-Beurrier V, Gilly FN, Bibeau F

Oxaliplatin-based versus irinotecan-based hyperthermic intraperitoneal chemotherapy (HIPEC) in patients with peritoneal metastasis from appendiceal and colorectal cancer: a retrospective analysis
Glockzin G, Gerken M, Lang SA, Klinkhammer-Schalke M, Piso P, Schlitt HJ

Recurrence and outcome after complete tumour removal and hyperthermic intraperitoneal chemotherapy in 512 patients with pseudomyxoma peritonei from perforated appendiceal mucinous tumours
Lord AC, Shihab O, Chandrakumaran K, Mohamed F, Cecil TD, Moran BJ

Outcome of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy on Patients with Diaphragmatic Involvement
Franssen B, Tabrizian P, Weinberg A, Romanoff A, Tuvin D, Labow D, Sarpel U

* Genome-wide mutational landscape of mucinous carcinomatosis peritonei of appendiceal origin
Alakus H, Babicky ML, Ghosh P, Yost S, Jepsen K, Dai Y, Arias A, Samuels ML, Mose ES, Schwab RB, Peterson MR, Lowy AM, Frazer KA, Harismendy O

* Frequent lack of GNAS mutations in colorectal adenocarcinoma associated with GNAS-mutated villous adenoma
Sekine S, Ogawa R, Oshiro T, Kanemitsu Y, Taniguchi H, Kushima R, Kanai Y

FOLFOX-4 Chemotherapy for Patients With Unresectable or Relapsed Peritoneal Pseudomyxoma
Pietrantonio F, Maggi C, Fanetti G, Iacovelli R, Di Bartolomeo M, Ricchini F, Deraco M, Perrone F, Baratti D, Kusamura S, Tamborini E, Castano A, Consonni PV, Bossi I, Gavazzi C, Milione M, Pelosi G, de Braud F

Predictors of Progression in High-Grade Appendiceal or Colorectal Peritoneal Carcinomatosis After Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy
Baumgartner JM1, Tobin L, Heavey SF, Kelly KJ, Roeland EJ, Lowy AM

GNAS is frequently mutated in both low-grade and high-grade disseminated appendiceal mucinous neoplasms but does not affect survival
Singhi AD, Davison JM, Choudry HA, Pingpank JF, Ahrendt SA, Holtzman MP, Zureikat AH, Zeh HJ, Ramalingam L, Mantha G, Nikiforova M, Bartlett DL, Pai RK

Molecular Profiling of Appendiceal Epithelial Tumors Using Massively Parallel Sequencing to Identify Somatic Mutations
Liu X, Mody K, de Abreu FB, Pipas JM, Peterson JD, Gallagher TL, Suriawinata AA, Ripple GH, Hourdequin KC, Smith KD, Barth RJ Jr, Colacchio TA, Tsapakos MJ, Zaki BI, Gardner TB, Gordon SR, Amos CI, Wells WA, Tsongalis GJ

Significance of Proximal Margin Involvement in Low-Grade Appendiceal Mucinous Neoplasms
Arnason T, Kamionek M, Yang M, Yantiss RK, Misdraji J

Secreted mucins in pseudomyxoma peritonei: pathophysiological significance and potential therapeutic prospects
Amini A, Masoumi-Moghaddam S, Ehteda A, Morris DL

Pseudomyxoma peritonei: inflammatory responses in the peritoneal microenvironment
Lohani K, Shetty S, Sharma P, Govindarajan V, Thomas P, Loggie B

Perioperative systemic chemotherapy for appendiceal mucinous carcinoma peritonei treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy
Blackham AU, Swett K, Eng C, Sirintrapun J, Bergman S, Geisinger KR, Votanopoulos K, Stewart JH, Shen P, Levine EA

Efficacy of cytoreductive surgery with hyperthermic intraperitoneal chemotherapy in the management of malignant ascites
Randle RW, Swett KR, Swords DS, Shen P, Stewart JH, Levine EA, Votanopoulos KI

* Orthotopic Animal Model of Pseudomyxoma Peritonei: An in Vivo Model to Test Anti-Angiogenic Drug Effects|Dohan A, Lousquy R, Eveno C, Goere D, Broqueres-You D, Kaci R, Lehmann-Che J, Launay JM, Soyer P, Bonnin P, Pocard M

Signifigance of signet ring cells in high-grade mucinous adenocarcinoma of the peritoneum from appendiceal origin
Sirintrapun SJ, Blackham AU, Russell G, Votanopoulos K, Stewart JH, Shen P, Levine EA, Geisinger KR, Bergman S

Molecular Profiling of Appendiceal Epithelial Tumors Using Massively Parallel Sequencing to Identify Somatic Mutations
Liu X, Mody K, de Abreu FB, Pipas JM, Peterson JD, Gallagher TL, Suriawinata AA, Ripple GH, Hourdequin KC, Smith KD, Barth RJ Jr, Colacchio TA, Tsapakos MJ, Zaki BI, Gardner TB, Gordon SR, Amos CI, Wells WA, Tsongalis GJ

Cytoreductive surgery plus perioperative intraperitoneal chemotherapy in pseudomyxoma peritonei: Aspects of the learning curve
Andréasson H, Lorant T, Påhlman L, Graf W, Mahteme H

Significance of urinary tract involvement in patients treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC)
Votanopoulos KI, Randle RW, Craven B, Swett KR, Levine EA, Shen P, Stewart JH, Mirzazadeh M

Current concepts in pseudomyxoma peritonei
Carr NJ

Peritoneal pseudomyxoma: An overview emphasizing pathological assessment and therapeutic strategies
Dartigues P, Isaac S, Villeneuve L, Glehen O, Capovilla M, Chevallier A, Croce S, Kaci R, Lang-Averous G, Laverriere MH, Leroux-Broussier A, Mery E, Poizat F, Valmary-Degano S, Verriele-Beurrier V, Gilly FN, Bibeau F

The RENAPE network: Towards a new healthcare organization for the treatment of rare tumors of the peritoneum. Description of the network and role of the pathologists
Villeneuve L, Isaac S, Glehen O, Capovilla M, Chevallier A, Croce S, Dartigues P, Fontaine J, Kaci R, Lang-Averous G, Laverriere MH, Leroux-Broussier A, Mery E, Poizat F, Valmary-Degano S, Verriele-Beurrier V, Gilly FN, Bibeau F

Role of hyperthermic intraoperative peritoneal chemotherapy in the management of peritoneal metastases
Elias D, Goéré D, Dumont F, Honoré C, Dartigues P, Stoclin A, Malka D, Boige V, Ducreux M

Pre-operative tumour marker status predicts recurrence and survival after complete cytoreduction and hyperthermic intraperitoneal chemotherapy for appendiceal Pseudomyxoma Peritonei: Analysis of 519 patients
Taflampas P, Dayal S, Chandrakumaran K, Mohamed F, Cecil TD, Moran BJ

Whole abdominopelvic radiotherapy in the palliative treatment of pseudomyxoma peritonei
Berkovic P, van de Voorde L, De Meerleer G, Delrue L, Speleers B, Van Belle S, Vandecasteele K

Studies Published - 2013
Intraperitoneal chemotherapy for peritoneal surface malignancy: experience with 1,000 patients
Levine EA, Stewart JH 4th, Shen P, Russell GB, Loggie BL, Votanopoulos KI

Predicting postoperative morbidity following cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CS+HIPEC) with preoperative FACT-C (Functional Assessment of Cancer Therapy) and patient-rated performance status
Ihemelandu CU, McQuellon R, Shen P, Stewart JH, Votanopoulos K, Levine EA

Obesity and peritoneal surface disease: outcomes after cytoreductive surgery with hyperthermic intraperitoneal chemotherapy for appendiceal and colon primary tumors
Votanopoulos KI, Swords DS, Swett KR, Randle RW, Shen P, Stewart JH, Levine EA

* Concurrent MCL1 and JUN amplification in pseudomyxoma peritonei: a comprehensive genetic profiling and survival analysis
Sio TT, Mansfield AS, Grotz TE, Graham RP, Molina JR, Que FG, Miller RC.

Surgical Outcomes of Hyperthermic Intraperitoneal Chemotherapy: Analysis of the American College of Surgeons National Surgical Quality Improvement Program
Jafari MD, Halabi WJ, Stamos MJ, Nguyen VQ, Carmichael JC, Mills SD, Pigazzi A

Melphalan: A Promising Agent in Patients Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy
Sardi A, Jimenez W, Nieroda C, Sittig M, Shankar S, Gushchin V

HIPEC + EPIC versus HIPEC-alone: differences in major complications following cytoreduction surgery for peritoneal malignancy
McConnell YJ, Mack LA, Francis WP, Ho T, Temple WJ

Proposed classification of pseudomyxoma peritonei: influence of signet ring cells on survival
Shetty S, Natarajan B, Thomas P, Govindarajan V, Sharma P, Loggie B

The role of VEGFR-2 expression in outcomes and survival of patients with peritoneal carcinomatosis from appendiceal cancer
Jimenez WA, Sardi A, Ledakis P, Nieroda C, Sittig M, Gushchin V

Repeated cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in peritoneal carcinomatosis from appendiceal cancer: analysis of survival outcomes
Sardi A, Jimenez WA, Nieroda C, Sittig M, Macdonald R, Gushchin V

* Frequent GNAS mutations in low-grade appendiceal mucinous neoplasms
Nishikawa G, Sekine S, Ogawa R, Matsubara A, Mori T, Taniguchi H, Kushima R, Hiraoka N, Tsuta K, Tsuda H, Kanai Y

A formulation for in situ lysis of mucin secreted in pseudomyxoma peritonei
Pillai K, Akhter J, Chua TC, Morris DL

Quality of Life Study following Cytoreductive Surgery and Intraperitoneal Chemotherapy for Pseudomyxoma Peritonei including Redo Procedures
Rachel Kirby,  Winston Liauw, Jing Zhao, and David Morris

Outcomes of Cytoreductive Surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) in patients older than 70 years; survival benefit at considerable morbidity and mortality
Votanopoulos KI, Newman NA, Russell G, Ihemelandu C, Shen P, Stewart JH, Levine EA

Carbohydrate antigen 19-9 (CA 19-9) is an independent prognostic indicator in pseudomyxoma peritonei post cytoreductive surgery and perioperative intraperitoneal chemotherapy
Koh JL, Liauw W, Chua T, Morris DL

A core microbiome associated with the peritoneal tumors of pseudomyxoma peritonei
Gilbreath JJ, Semino-Mora C, Friedline CJ, Liu H, Bodi KL, McAvoy TJ, Francis J, Nieroda C, Sardi A, Dubois A, Lazinski DW, Camilli A, Testerman TL, Merrell DS.

Antibiotic Treatment Decreases Microbial Burden Associated with Pseudomyxoma Peritonei and Affects β-catenin Distribution
Semino-Mora C, Testerman TL, Liu H, Whitmire JM, Studeman K, Jia Y, McAvoy TJ, Francis J, Nieroda C, Sardi A, Merrell DS, Dubois A.

The incidence of mucinous appendiceal malignancies: a population-based study
van den Heuvel MG, Lemmens VE, Verhoeven RH, de Hingh IH

Extensive Cytoreductive Surgery for Appendiceal Carcinomatosis: Morbidity, Mortality, and Survival
Wagner PL, Austin F, Maduekwe U, Mavanur A, Ramalingam L, Jones HL, Holtzman MP, Ahrendt SA, Zureikat AH, Pingpank JF, Zeh HJ, Bartlett DL, Choudry HA

* Chronic anti-inflammatory drug therapy inhibits gel-forming mucin production in a murine xenograft model of human pseudomyxoma peritonei
Choudry HA, Mavanur A, O'Malley ME, Zeh HJ, Guo Z, Bartlett DL

* Mucin as a therapeutic target in pseudomyxoma peritonei
Choudry HA, O'Malley ME, Guo ZS, Zeh HJ, Bartlett DL.

* Life after death: targeting high mobility group box 1 in emergent cancer therapies
Z Sheng Guo, Zuqiang Liu, David L Bartlett, Daolin Tang, and Michael T Lotze

Current status and future directions in appendiceal cancer with peritoneal dissemination
Votanopoulos KI, Shen P, Stewart JH 4th, Levine EA

Mucinous neoplasms of the appendix: a current comprehensive clinicopathologic and imaging review
Sree Harsha Tirumani, Margaret Fraser-Hill, Rebecca Auer, Wael Shabana, Cynthia Walsh, Frank Lee, and John G. Ryan

Studies Published - 2012
Significance of Serum Tumor Marker Levels in Peritoneal Carcinomatosis of Appendiceal Origin
Wagner PL, Austin F, Sathaiah M, Magge D, Maduekwe U, Ramalingam L, Jones HL, Holtzman MP, Ahrendt SA, Zureikat AH, Pingpank JF, Zeh HJ 3rd, Bartlett DL, Choudry HA

Systemic Chemotherapy prior to Cytoreductive Surgery and HIPEC for Carcinomatosis from Appendix Cancer: Impact on Perioperative Outcomes and Short-Term Survival
Bijelic L, Kumar AS, Stuart OA, Sugarbaker PH

Quality of Life in Patients after Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy: Is It Worth the Risk?
Tsilimparis N, Bockelmann C, Raue W, Menenakos C, Perez S, Rau B, Hartmann J.

Delay of cytoreductive surgery and heated intraperitoneal chemotherapy in patients with appendiceal neoplasm
El Halabi H, Macdonald R, Studeman K, Francis J, Nieroda C, Gushchin V, Sardi A

Inflammatory Markers in Blood and Serum Tumor Markers Predict Survival in Patients With Epithelial Appendiceal Neoplasms Undergoing Surgical Cytoreduction and Intraperitoneal Chemotherapy
Chua TC, Chong CH, Liauw W, Zhao J, Morris DL

Pseudomyxoma peritonei of 92 Chinese patients: Clinical characteristics, pathological classification and prognostic factors
Ai-Tao Guo, Yan-Mi Li, Li-Xin Wei

Pathology and prognosis in pseudomyxoma peritonei: a review of 274 cases
Carr NJ, Finch J, Ilesley IC, Chandrakumaran K, Mohamed F, Mirnezami A, Cecil T, Moran B

Outcomes of repeat cytoreductive surgery with hyperthermic intraperitoneal chemotherapy for the treatment of peritoneal surface malignancy
Votanopoulos KI, Ihemelandu C, Shen P, Stewart JH, Russell GB, Levine EA

Mucin as a therapeutic target in pseudomyxoma peritonei
Sugarbaker PH, Stuart OA, Eger C

Pharmacokinetics of Hyperthermic Intrathoracic Chemotherapy following Pleurectomy and Decortication
Choudry HA, O'Malley ME, Guo ZS, Zeh HJ, Bartlett DL

Classification of and cytoreductive surgery for low-grade appendiceal mucinous neoplasms
McDonald JR, O'Dwyer ST, Rout S, Chakrabarty B, Sikand K, Fulford PE, Wilson MS, Renehan AG

Experience after 100 patients treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy
Königsrainer I, Zieker D, Glatzle J, Lauk O, Klimek J, Symons S, Brücher B, Beckert S, Königsrainer A

A comparison of hematologic toxicity profiles after heated intraperitoneal chemotherapy with oxaliplatin and mitomycin C
Votanopoulos K, Ihemelandu C, Shen P, Stewart J, Russell G, Levine EA

No-incision (NOTES) versus single-incision (single-port) surgery for access to sites of peritoneal carcinomatosis: a back-to-back animal study
Ladjici Y, Pocard M, Marteau P, Valleur P, Dray X

Preoperative assessment of peritoneal carcinomatosis: intraindividual comparison of 18F-FDG PET/CT and MRI
Klumpp BD, Schwenzer N, Aschoff P, Miller S, Kramer U, Claussen CD, Bruecher B, Koenigsrainer A, Pfannenberg C

Gastrointestinal complications in 147 consecutive patients with peritoneal surface malignancy treated by cytoreductive surgery and perioperative intraperitoneal chemotherapy
Casado-Adam A, Alderman R, Stuart OA, Chang D, Sugarbaker PH

Addition of Biological Therapies to Palliative Chemotherapy Prolongs Survival in Patients With Peritoneal Carcinomatosis of Colorectal Origin
Klaver YL, Leenders BJ, Creemers GJ, Rutten HJ, Verwaal VJ, Lemmens VE, de Hingh IH

CT imaging interval after complete cytoreductive surgery/hyperthermic intraperitoneal chemotherapy (HIPEC) for well-differentiated adenocarcinoma of the appendix (WDAA)
Karen A. Beaty, Joshua S. Hill, Safia Rafeeq, Michael J. Overman, Tara L. Sagebiel, Aurelio Matamoros, Richard E. Royal, Paul F. Mansfield, Keith F. Fournier; University of Texas M. D. Anderson Cancer Center, Houston, TX

Early and long-term outcome data on 2,298 patients with pseudomyxoma peritonei of appendiceal origin treated by a strategy of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy
Terence C. Chua, Brendan J. Moran, Paul H. Sugarbaker, Edward Allen Levine, Olivier Glehen, Francois N. Gilly, Dominique Elias, Dario Baratti, Marcello Deraco, Armando Sardi, David L. Morris, Peritoneal Surface Oncology Group International; University of New South Wales, Sydney, Australia; NCG Pseudomyxoma Peritonei Centre, The North Hampshire Hospital, Basingstoke, United Kingdom; Washington Hospital Center, Washington, DC; Wake Forest School of Medicine, Winston-Salem, NC; Centre Hospitalo-Universitaire Lyon Sud, Lyon, France; Institut Gustave Roussy, Villejuif, France; Istituto Nazionale per la Cura e lo Studio dei Tumori , Milan, Italy; Mercy Medical Center, Baltimore, MD

Impact of tumor aneuploidy in pseudomyxoma peritonei
Shreya Jagadish Shetty, Bala Natarajan, Brian W. Loggie; Creighton University Medical Center, Omaha, NE

Histopathological Classification of Pseudomyxoma Peritonei and the Prognostic Importance of PINCH Protein
Andréasson H, Wanders A, Sun XF, Willén R, Graf W, Nygren P, Glimelius B, Zhang ZY, Mahteme H

The Influence of Tumor Cell Entrapment Phenomenon on the Natural History of Pseudomyxoma peritonei Syndrome
Spiliotis J, Efstathiou E, Halkia E, Vaxevanidou A, Datsis A, Sugarbaker P.

Multidimensional analysis of the learning curve for cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in peritoneal surface malignancies
Kusamura S, Baratti D, Deraco M

Flexible versus rigid single-port peritoneoscopy: a randomized controlled trial in a live porcine model followed by initial experience in human cadavers
Ladjici Y, Dray X, Marteau P, Valleur P, Pocard M

Critical role of hyperthermic intraperitoneal chemoperfusion in the treatment of a patient with Pseudomyxoma peritonei
Cole KL, Choudry HA, Jones HL, Goodell PP, Bartlett DL

Right hemicolectomy is not routinely indicated in pseudomyxoma peritonei
Foster JM, Gupta PK, Carreau JH, Grotz TE, Blas JV, Gatalica Z, Nath S, Loggie BW

Peritoneal Carcinomatosis: Cytoreductive Surgery and HIPEC--Overview and Basics
Brücher BL, Piso P, Verwaal V, Esquivel J, Derraco M, Yonemura Y, Gonzalez-Moreno S, Pelz J, Königsrainer A, Ströhlein M, Levine EA, Morris D, Bartlett D, Glehen O, Garofalo A, Nissan A

Gene Expression Profiling of Peritoneal Metastases from Appendiceal and Colon Cancer Demonstrates Unique Biologic Signatures and Predicts Patient Outcomes
Levine EA, Blazer DG 3rd, Kim MK, Shen P, Stewart JH 4th, Guy C, Hsu DS

Immunohistochemical and biochemical characterization of mucin in pseudomyxoma peritonei: a case study
Mall AS, Lotz Z, Tyler M, Goldberg P, Rodrigues J, Kahn D, Chirwa N, Govender D

Pharmacokinetic study of perioperative intravenous Ifosfamide
Van der Speeten K, Stuart OA, Mahteme H, Sugarbaker PH

Studies Published - 2011
Mucolysis by Ascorbic Acid and Hydrogen Peroxide on Compact Mucin Secreted in Pseudomyxoma Peritonei
Pillai K, Akhter J, Chua TC, Morris DL

Multidimensional Analysis of Learning Curve for Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy in Peritoneal Surface Malignancies
Kusamura S, Baratti D, Deraco M

Multimodal Treatment Approaches for Peritoneal Carcinomatosis in Colorectal Cancer
Piso P, Arnold D

Clinical efficacy of cytoreductive surgery and hyperthermic chemotherapy in peritoneal carcinomatosis from gastric cancer
Ströhlein MA, Bulian DR, Heiss MM

Peritoneal carcinomatosis: imaging with 64-MDCT and 3T MRI with diffusion-weighted imaging
Iafrate F, Ciolina M, Sammartino P, Baldassari P, Rengo M, Lucchesi P, Sibio S, Accarpio F, Di Giorgio A, Laghi A

Mucinous neoplasms of the appendix and peritoneum
Panarelli NC, Yantiss RK

Cancers of the Appendix: Review of the Literatures
Carl Ruoff, Louay Hanna, Wanqing Zhi, Ghulamullah Shahzad, Vladimir Gotlieb, and Muhammad Wasif Saif

Treatment of gastric cancer with peritoneal carcinomatosis by cytoreductive surgery and HIPEC: A systematic review of survival, mortality, and morbidity
Gill RS, Al-Adra DP, Nagendran J, Campbell S, Shi X, Haase E, Schiller D

Preparation of camptothecin-loaded PCEC microspheres for the treatment of colorectal peritoneal carcinomatosis and tumor growth in mice
Dai M, Xu X, Song J, Fu S, Gou M, Luo F, Qian Z

Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy as upfront therapy for advanced epithelial ovarian cancer: multi-institutional phase-II trial
Deraco M, Kusamura S, Virzì S, Puccio F, Macrì A, Famulari C, Solazzo M, Bonomi S, Iusco DR, Baratti D

Cytoreductive surgery with intraperitoneal chemotherapy to treat pseudomyxoma peritonei at nonspecialized hospitals
Kitai T, Kawashima M, Yamanaka K, Ichijima K, Fujii H, Mashima S, Shimahara Y

Appendiceal adenocarcinoids with peritoneal carcinomatosis treated with cytoreductive surgery and intraperitoneal chemotherapy: a retrospective study of in vitro drug sensitivity and survival
Cashin P, Nygren P, Hellman P, Granberg D, Andréasson H, Mahteme H

Early recurrence of pseudomyxoma peritonei following treatment failure of cytoreductive surgery and perioperative intraperitoneal chemotherapy is indicative of a poor survival outcome
Chua TC, Liauw W, Morris DL

Cytoreductive surgery and HIPEC in peritoneal recurrent ovarian cancer: experience and lessons learned
Königsrainer I, Beckert S, Becker S, Zieker D, Fehm T, Grischke EM, Lauk O, Glatzle J, Brücher B, Wallwiener D, Königsrainer A

Endoscopic ultrasound-guided fine needle aspiration of peritoneal nodules in patients with ascites of unknown cause
Rana SS, Bhasin DK, Srinivasan R, Singh K 

Management of peritoneal carcinomatosis from colorectal cancer
Ihemelandu CU, Shen P, Stewart JH, Votanopoulos K, Levine EA

Factors influencing early postoperative recovery after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy Arakelian E, Gunningberg L, Larsson J, Norlén K, Mahteme H

Outcomes of elderly patients undergoing cytoreductive surgery and perioperative intraperitoneal chemotherapy for colorectal cancer peritoneal carcinomatosis
Klaver YL, Chua TC, de Hingh IH, Morris DL

Systemic chemotherapy and surgical cytoreduction for poorly differentiated and signet ring cell adenocarcinomas of the appendix
Lieu CH, Lambert LA, Wolff RA, Eng C, Zhang N, Wen S, Rafeeq S, Taggart M, Fournier K, Royal R, Mansfield P, Overman MJ

Patients with high-grade appendix cancer and extensive disease do benefit from Cytoreduction and heated intraperitoneal chemotherapy if complete cytoreduction can be achieved
H.M. El Halabi, V. Gushchin, R. Macdonald, J. Francis, A. Sardi

Lymph node metastasis predicts survival in patients with highgrade appendix cancer
H.M. El Halabi, V. Gushchin, R. Macdonald, J. Francis, N. Athas, A. Sardi

Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy as upfront therapy for advanced epithelial ovarian cancer: Multi-institutional phase-II trial
Deraco M, Kusamura S, Virzì S, Puccio F, Macrì A, Famulari C, Solazzo M, Bonomi S, Iusco DR, Baratti D

Reappraisal of the role of hyperthermic intraperitoneal chemotherapy (HIPEC) in the management of ovarian cancer: a single institutional experience
Melis A, Abboud K, Bourmaud A, Pacaut C, Bageacu S, Jacquin JP, Porcheron J, Merrouche Y, Magné N

Bologna Guidelines for Diagnosis and Management of Adhesive Small Bowel Obstruction (ASBO): 2010 Evidence-Based Guidelines of the World Society of Emergency Surgery Catena F, Di Saverio S, Kelly MD, Biffl WL, Ansaloni L, Mandalà V, Velmahos GC, Sartelli M, Tugnoli G, Lupo M, Mandalà S, Pinna AD, Sugarbaker PH, Van Goor H, Moore EE, Jeekel J

Impact of surgical and clinical factors on the pharmacology of intraperitoneal doxorubicin in 145 patients with peritoneal carcinomatosis
Sugarbaker PH, Van der Speeten K, Anthony Stuart O, Chang D

Surgical cytoreduction and survival in appendiceal cancer peritoneal carcinomatosis: an evaluation of 46 consecutive patients
Chua TC, Al-Alem I, Saxena A, Liauw W, Morris DL

Peritoneal carcinomatosis from appendiceal cancer: early adequate therapeutic management for long-term survival
Glehen O, Bakrin N, Passot G

Rationale for Heating Oxaliplatin for the Intraperitoneal Treatment of Peritoneal Carcinomatosis: A Study of the Effect of Heat on Intraperitoneal Oxaliplatin Using a Murine Model
Piché N, Leblond FA, Sidéris L, Pichette V, Drolet P, Fortier LP, Mitchell A, Dubé P

Hyperthermia and Intraperitoneal Chemotherapy for the Treatment of Peritoneal Carcinomatosis: An Experimental Study
Klaver YL, Hendriks T, Lomme RM, Rutten HJ, Bleichrodt RP, de Hingh IH

Feasibility of Delayed Hyperthermic Intraperitoneal Chemotherapy in Case of Unforeseen Complications
Mohr Z, Hirche C, Liebeskind U, Rau B, Hünerbein M

Primary appendiceal mucinous adenocarcinoma in two first-degree relatives: case report and review
Racek AR Msii, Rabe KG M S, Wick MJ M D Ph D, Psychogios A M D, Lindor NM M D

Long-term follow-up in the treatment of peritoneal carcinomatosis
Hamilton T, Lanuke K, Mack LA, Temple WJ

Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy improves survival of gastric cancer with peritoneal carcinomatosis: evidence from an experimental study
Tang L, Mei LJ, Yang XJ, Huang CQ, Zhou YF, Yonemura Y, Li Y

A new standard of care for the management of peritoneal surface malignancy
Mohamed F, Cecil T, Moran B, Sugarbaker P

Pseudomyxoma peritonei treated by cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: results from a single centre
Arjona-Sánchez A, Muñoz-Casares FC, Rufián-Peña S, Díaz-Nieto R, Casado-Adam A, Rubio-Pérez MJ, Ortega-Salas R

Upfront compared to delayed cytoreductive surgery and perioperative intraperitoneal chemotherapy for pseudomyxoma peritonei is associated with considerably lower perioperative morbidity and recurrence rate
Chua TC, Liauw W, Zhao J, Morris DL

Unresectable peritoneal carcinomatosis from colorectal cancer: A single center experience
Hompes D, Boot H, van Tinteren H, Verwaal V

Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy Improves Survival of Patients with Peritoneal Carcinomatosis from Gastric Cancer: Final Results of a Phase III Randomized Clinical Trial
Yang XJ, Huang CQ, Suo T, Mei LJ, Yang GL, Cheng FL, Zhou YF, Xiong B, Yonemura Y, Li Y

Closed Abdomen Hyperthermic Intraperitoneal Chemotherapy with Irinotecan and Mitomycin C: a Phase I Study
Cotte E, Passot G, Tod M, Bakrin N, Gilly FN, Steghens A, Mohamed F, Glehen O

Netrin-4 Delays Colorectal Cancer Carcinomatosis by Inhibiting Tumor Angiogenesis
Eveno C, Broqueres-You D, Feron JG, Rampanou A, Tijeras-Raballand A, Ropert S, Leconte L, Levy BI, Pocard M

Results of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy after early failure of adjuvant systemic chemotherapy
Klaver YL, de Hingh IH, Boot H, Verwaal VJ

Literature review of the efficacy and safety of hyperthermic intraperitoneal perfusion chemotherapy after cytoreductive surgery in the treatment of pseudomyxoma peritonei
Ba MC, Cui SZ, Luo FT, Ouyang WW, Tang YQ, Wu YB, Tang HS

Ultrasonography findings and tumour quantification in patients with pseudomyxoma peritonei
Krause J, Bergman A, Graf W, Nilsson A, Mahteme H

Childbearing After Hyperthermic Intraperitoneal Chemotherapy: Results From an International Survey
Ortega-Deballon P, Glehen O, Levine E, Piso P, Sugarbaker PH, Hayes-Jordan A, Facy A, Bakrin N, Rat P

Operative findings, early complications, and long-term survival in 456 patients with pseudomyxoma peritonei syndrome of appendiceal origin
Youssef H, Newman C, Chandrakumaran K, Mohamed F, Cecil TD, Moran BJ

On or in the liver? Two cases with diffuse pseudomyxoma peritonei and synchronous hepatic pathology
Youssef H, Moran BJ

Determining the Association Between Preoperative Computed Tomography Findings and Postoperative Outcomes After Cytoreductive Surgery and Perioperative Intraperitoneal Chemotherapy for Pseudomyxoma Peritonei
Chua TC, Al-Zahrani A, Saxena A, Glenn D, Liauw W, Zhao J, Morris DL

Influence of Modern Systemic Therapies as Adjunct to Cytoreduction and Perioperative Intraperitoneal Chemotherapy for Patients With Colorectal Peritoneal Carcinomatosis: A Multicenter Study
Chua TC, Morris DL, Saxena A, Esquivel J, Liauw W, Doerfer J, Germer CT, Kerscher AG, Pelz JO

Studies Published - 2010
Clinical utility of elevated tumor markers in patients with disseminated appendiceal malignancies treated by cytoreductive surgery and HIPEC
Ross A, Sardi A, Nieroda C, Merriman B, Gushchin V

Revised guidelines for second-look surgery in patients with colon and rectal cancer
Sugarbaker PH

Accuracy and clinical relevance of computed tomography scan interpretation of peritoneal cancer index in colorectal cancer peritoneal carcinomatosis: a multi-institutional study
Esquivel J, Chua TC, Stojadinovic A, Melero JT, Levine EA, Gutman M, Howard R, Piso P, Nissan A, Gomez-Portilla A, Gonzalez-Bayon L, Gonzalez-Moreno S, Shen P, Stewart JH, Sugarbaker PH, Barone RM, Hoefer R, Morris DL, Sardi A, Sticca RP

Pharmacology of perioperative 5-fluorouracil
Van der Speeten K, Stuart OA, Mahteme H, Sugarbaker PH

Use of FDG-PET imaging for patients with disseminated cancer of the appendix
Rohani P, Scotti SD, Shen P, Stewart JH, Russell GB, Cromer M, Levine EA

Indication of Peritonectomy for Peritoneal Dissemination
Yonemura Y, Tsukiyama G, Miyata R, Sako S, Endou Y, Hirano M, Mizumoto A, Matsuda T, Takao N, Ichinose M, Miura M, Hagiwara A, Li Y

Results of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy after early failure of adjuvant systemic chemotherapy
Klaver YL, de Hingh IH, Boot H, Verwaal VJ

Selection of patients and staging of peritoneal surface malignancies
Eddy Cotte, Guillaume Passot, François-Noël Gilly, and Olivier Glehen 

New approach to peritoneal surface malignancies
Antonio Macrì, Department of Human Pathology, General Surgery Unit, University of Messina, 98125 Messina, Italy.

Clinical presentation of pseudomyxoma peritonei
Järvinen P, Lepistö A. Department of Surgery, Helsinki University Central Hospital, Helsinki, Finland.

Prognostic factors and oncologic outcome in 146 patients with colorectal peritoneal carcinomatosis treated with cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy: Italian multicenter study S.I.T.I.L.O.
Cavaliere F, De Simone M, Virzì S, Deraco M, Rossi CR, Garofalo A, Di Filippo F, Giannarelli D, Vaira M, Valle M, Pilati P, Perri P, La Pinta M, Monsellato I, Guadagni F. Department of Surgery, San Giovanni Hospital, Via dell'Amba Aradam 9, 00184 Rome, Italy.

Pharmacologic rationale for treatments of peritoneal surface malignancy from colorectal cancer
Sugarbaker PH, Van der Speeten K, Stuart OA.

Pseudomyxoma peritonei
Katharine E Bevan, Faheez Mohamed and Brendan J Moran

Appendiceal mucinous neoplasms: controversial isses
Misdraji J

Bevacizumab for the Treatment of Non-Resectable Pseudomyxoma peritonei Associated with Mucinous Ovarian Tumor of Low Malignant Potential – A Comparison of Two Cases
Ira Winer and Ronald J. Buckanovich

A pharmacological review on intraperitoneal chemotherapy for peritoneal malignancy Tristan D Yan, Christopher Qian Cao and Stine Munkholm-Larsen.

Peritoneal-based malignancies and their treatment
Teo M.

Pseudomyxoma peritonei: a French multicentric study of 301 patients treated with cytoreductive surgery and intraperitoneal chemotherapy
Elias D, Gilly F, Quenet F, Bereder JM, Sidéris L, Mansvelt B, Lorimier G, Glehen O; Association Française de Chirurgie.

A clinicopathologic analysis of peritoneal metastases of colorectal and appendiceal origin
Bruin SC, Verwaal VJ, Vincent A, van't Veer LJ, van Velthuysen ML.

Surgical responsibilities in the management of peritoneal carcinomatosis
Sugarbaker PH.

Cytoreductive surgery and hyperthermic intraperitoneal chemoperfusion versus systemic chemotherapy alone for colorectal peritoneal carcinomatosis
Franko J, Ibrahim Z, Gusani NJ, Holtzman MP, Bartlett DL, Zeh HJ 3rd.

Curative treatment of colorectal peritoneal carcinomatosis: current status and future trends
Maggiori L, Elias D.

Mucinous adenocarcinomas with intra-abdominal dissemination: a review of current therapy
Winder T, Lenz HJ.

Prospective study of quality of life after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy using oxaliplatin for peritoneal carcinomatosis
Lim C, Tordjmann D, Gornet JM, Nemeth J, Valleur P, Pocard M.

Secondary Cytoreduction and Perioperative Intraperitoneal Chemotherapy after Initial Debulking of Pseudomyxoma Peritonei: A Study of Timing and the Impact of Malignant Dedifferentiation
Chua TC, Al-Zahrani A, Saxena A, Liauw W, Zhao J, Morris DL.

Toward curative treatment of peritoneal carcinomatosis from nonovarian origin by cytoreductive surgery combined with perioperative intraperitoneal chemotherapy: a multi-institutional study of 1290 patients
Glehen O, Gilly FN, Boutitie F, Bereder JM, Quenet F, Sideris L, Mansvelt B, Lorimier G, Msika S, Elias D; the French Surgical Association.

Intraoperative hyperthermic intraperitoneal chemotherapy after cytoreductive surgery for peritoneal carcinomatosis in an experimental model
Klaver YL, Hendriks T, Lomme RM, Rutten HJ, Bleichrodt RP, de Hingh IH.

Evolution of locoregional treatment for peritoneal carcinomatosis: single-center experience of 308 procedures of cytoreductive surgery and perioperative intraperitoneal chemotherapy
Chua TC, Liauw W, Saxena A, Al-Mohaimeed K, Fransi S, Zhao J, Morris DL

Studies Published - 2009
Peritoneal colorectal carcinomatosis treated with surgery and perioperative intraperitoneal chemotherapy: retrospective analysis of 523 patients from a multicentric French study
Elias D, Gilly F, Boutitie F, Quenet F, Bereder JM, Mansvelt B, Lorimier G, Dubè P, Glehen O

Epithelial appendiceal neoplasms
Sugarbaker PH

Laparoscopic Mucin Removal in Patients With Pseudomyxoma Peritonei
Albedah, A

Simultaneous bicavitary hyperthermic chemoperfusion in the management of pseudomyxoma peritonei with synchronous pleural extension
Senthil M, Harrison LE

Complete cytoreduction offers longterm survival in patients with peritoneal carcinomatosis from appendiceal tumors of unfavorable histology
Omohwo C, Nieroda CA, Studeman KD, Thieme H, Kostuik P, Ross AS, Holter DR, Gushchin V, Merriman B, Sardi A

Modern systemic chemotherapy in surgically unresectable neoplasms of appendiceal origin: a single-institution experience
Shapiro JF, Chase JL, Wolff RA, Lambert LA, Mansfield PF, Overman MJ, Ohinata A, Liu J, Wang X, Eng C

Diffusion-weighted MRI of peritoneal tumors: comparison with conventional MRI and surgical and histopathologic findings--a feasibility study 
Low RN, Sebrechts CP, Barone RM, Muller W

Comprehensive management of peritoneal surface malignancy using cytoreductive surgery and perioperative intraperitoneal chemotherapy: the Washington Cancer Institute approach
Sugarbaker PH

Management of pseudomyxoma peritonei by cytoreduction+HIPEC (hyperthermic intraperitoneal chemotherapy): results analysis of a twelve-year experience
Vaira M, Cioppa T, DE Marco G, Bing C, D'Amico S, D'Alessandro M, Fiorentini G, DE Simone M

Incidence, Risk Factors, and Impact of Severe Neutropenia After Hyperthermic Intraperitoneal Mitomycin C
Lambert, Laura A.; Armstrong, Terri S.; Lee, J. Jack; Liu, Suyu; Katz, Matthew H.; Eng, Cathy;et. al.

In vivo model of pseudomyxoma peritonei for novel candidate drug discovery
Chua TC, Akther J, Yao P, Morris DL.

Primary peritonectomy/HIPEC for disseminated peritoneal adenomucinosis achieves much lower recurrence rates and better survival than secondary procedures.
Zhu KJ, Morris DL.

Pseudomyxoma Peritonei: A Need to Establish Evidence-Based Standard of Care—Is This the Right Trial?
Terence C. Chua, BScMed (Hons), Khaled Al-Mohaimeed, MBBS, FRCS, Winston Liauw, MBBS, FRACP, and David L. Morris, MD, PhD

Successful antiangiogenic combination therapy for pseudomyxoma peritonei with bevacizumab and capecitabine
Sun WL, Hutarew G, Gradl J, Gratzl M, Denz H, Fiegl M

A prospective evaluation of venous thromboembolism in patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy
Lanuke K, Mack LA, Temple WJ

Studies Published - 2008
Consensus statement on the loco-regional treatment of appendiceal mucinous neoplasms with peritoneal dissemination (pseudomyxoma peritonei)
Moran B, Baratti D, Yan TD, Kusamura S, Deraco M

Appendiceal neoplasms and pseudomyxoma peritonei: a population based study
Smeenk RM, van Velthuysen ML, Verwaal VJ, Zoetmulder FA

Pseudomyxoma Peritonei: Is Disease Progression Related to Microbial Agents? A Study of Bacteria, MUC2 and MUC5AC Expression in Disseminated Peritoneal Adenomucinosis and Peritoneal Mucinous Carcinomatosis
Cristina Semino-Mora, Hui Liu, Thomas McAvoy, Carol Nieroda, Kimberley Studeman, Armando Sardi, and Andre Dubois

Peritoneal Pseudomyxoma: Results of a Systematic Policy of Complete Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy
Elias D, Honoré C, Ciuchendéa R, Billard V, Raynard B, Lo Dico R, Dromain C, Duvillard P, Goéré D

A Phase II Study Evaluating the Use of Concurrent Mitomycin C and Capecitabine (Xeloda) in Patients with Advanced Unresectable Pseudomyxoma Peritonei
Farquharson AL, Pranesh N, Witham G, Swindell R, Taylor MB, Renehan AG, Rout S, Wilson MS, O'Dwyer ST, Saunders MP

Mucinous Ovarian Tumors Associated with Pseudomyxoma Peritonei of Adenomucinosis Type: Immunohistochemical Evidence That They Are Secondary Tumors
Ferreira CR, Carvalho JP, Soares FA, Siqueira SA, Carvalho FM

Quality of Life After Cytoreductive Surgery plus Early Intraperitoneal Postoperative Chemotherapy for Pseudomyxoma Peritonei - A Prospective Study
Jess P, Iversen LH, Nielsen MB, Hansen F, Laurberg S, Rasmussen PC

Retrospective Multicenter Study of a Clinicopathological Analysis of Pseudomyxoma Peritonei Associated with Ovarian Tumors (KGOG 3005)
Lee JK, Song SH, Kim I, Lee KH, Kim BG, Kim JW, Kim YT, Park SY, Cha MS, Kang SB

Successful pregnancy in a patient with pseudomyxoma peritonei following in-vitro fertilization using donor eggs 
SA Narvekar, PK VijayKumar, N Shetty, MS Srinivas, and KA Rao

Pseudomyxoma peritonei. Over 10 years' survival after cytoreduction, intraperitoneal chemotherapy, and hyperthermia
Gómez Portilla A, Martínez de Lecea C, Gómez C, Cendoya I, Olabarría I, Camps B

Cytoreduction and hyperthermic intraperitoneal chemotherapy in the treatment of peritoneal carcinomatosis from pseudomyxoma peritonei
Cioppa T, Vaira M, Bing C, D'Amico S, Bruscino A, De Simone M

Pseudomyxoma peritonei: clinical pathological and biological prognostic factors in patients treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC)
Baratti D, Kusamura S, Nonaka D, Langer M, Andreola S, Favaro M, Gavazzi C, Laterza B, Deraco M

Studies Published - 2007
Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy in the Management of Peritoneal Surface Malignancies of Colonic Origin: A Consensus Statement
Esquivel J, Sticca R, Sugarbaker P, Levine E, Yan TD, Alexander R, Baratti D, Bartlett D, Barone R, Barrios P, Bieligk S, Bretcha-Boix P, Chang CK, Chu F, Chu Q, Daniel S, de Bree E, Deraco M, Dominguez-Parra L, Elias D, Flynn R, Foster J, Garofalo A, Gilly FN, Glehen O, Gomez-Portilla A, Gonzalez-Bayon L, Gonzalez-Moreno S, Goodman M, Gushchin V, Hanna N, Hartmann J, Harrison L, Hoefer R, Kane J, Kecmanovic D, Kelley S, Kuhn J, Lamont J, Lange J, Li B, Loggie B, Mahteme H, Mann G, Martin R, Misih RA, Moran B, Morris D, Onate-Ocana L, Petrelli N, Philippe G, Pingpank J, Pitroff A, Piso P, Quinones M, Riley L, Rutstein L, Saha S, Alrawi S, Sardi A, Schneebaum S, Shen P, Shibata D, Spellman J, Stojadinovic A, Stewart J, Torres-Melero J, Tuttle T, Verwaal V, Villar J, Wilkinson N, Younan R, Zeh H, Zoetmulder F, Sebbag G; Society of Surgical Oncology Annual Meeting.

HIPEC: The Complexities of Clinical Trials
Bartlett, D

Survival Analysis of Pseudomyxoma Peritonei Patients Treated by Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy
Robert M. Smeenk, MD, Vic J. Verwaal, MD, PhD, Ninja Antonini, MSc, and Frans A. N. Zoetmulder, MD, PhD

A systematic review on the efficacy of cytoreductive surgery and perioperative intraperitoneal chemotherapy for pseudomyxoma peritonei
Yan TD, Black D, Savady R, Sugarbaker PH

Mucinous Appendiceal Neoplasms: Preoperative MR Staging and Classification Compared with Surgical and Histopathologic Findings
Russell N. Low, Robert M. Barone, Jonathan M. Gurney, and Wayne D. Muller

HIPEC with Oxaliplatin in the Treatment of Peritoneal Carcinomatosis of Colorectal Origin
D Elias, M Pocard, D Goere

Critical analysis of treatment failure after complete cytoreductive surgery and perioperative intraperitoneal chemotherapy for peritoneal dissemination from appendiceal mucinous neoplasms
Yan TD, Bijelic L, Sugarbaker PH

Prognostic value of circulating tumor markers in patients with pseudomyxoma peritonei treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy
Baratti D, Kusamura S, Martinetti A, Seregni E, Laterza B, Oliva DG, Deraco M

Progression of Pseudomyxoma Peritonei after Combined Modality Treatment: Management and Outcome
Smeenk RM, Verwaal VJ, Antonini N, Zoetmulder FA

Learning curve of combined modality treatment in peritoneal surface disease
Smeenk RM, Verwaal VJ, Zoetmulder FA

Early results of surgery in 123 patients with pseudomyxoma peritonei from a perforated appendiceal neoplasm
Murphy EM, Sexton R, Moran BJ

Studies Published - 2006
Cytoreductive surgery and perioperative intraperitoneal chemotherapy for pseudomyxoma peritonei from appendiceal mucinous neoplasms
Yan TD, Links M, Xu ZY, Kam PC, Glenn D, Morris DL

Systematic Review on the Efficacy of Cytoreductive Surgery Combined With Perioperative Intraperitoneal Chemotherapy for Peritoneal Carcinomatosis From Colorectal Carcinoma
Yan TD, Black D, Savady R, Sugarbaker PH

Perioperative intraperitoneal chemotherapy for peritoneal surface malignancy
Tristan D Yan, Oswald A Stuart, Dal Yoo and Paul H Sugarbaker 

New standard of care for appendiceal epithelial neoplasms and pseudomyxoma peritonei syndrome?
Paul H Sugarbaker

Appendiceal neoplasms with peritoneal dissemination: outcomes after cytoreductive surgery and intraperitoneal hyperthermic chemotherapy
Stewart JH 4th, Shen P, Russell GB, Bradley RF, Hundley JC, Loggie BL, Geisinger KR, Levine EA

COX – 2 Expression in Pseudomyxoma Peritonei
Gatalica Z, Loggie B

Pseudomyxoma peritonei of appendiceal origin: a clinicopathologic analysis of 101 patients uniformly treated at a single institution, with literature review
Bradley RF, Stewart JH 4th, Russell GB, Levine EA, Geisinger KR

High Expression of RELP (Reg IV) in Neoplastic Goblet Cells of Appendiceal Mucinous Cystadenoma and Pseudomyxoma Peritonei
Heiskala K, Giles-Komar J, Heiskala M, Andersson LC

A Specific Cadherin Phenotype May Characterize the Disseminating Yet Non-Metastatic Behavior of Pseudomyxoma Peritonei
Bibi R, Pranesh N, Saunders MP, Wilson MS, O'dwyer ST, Stern PL, Renehan AG

Studies Published - 2005
Lymph node metastasis in epithelial malignancies of the appendix with peritoneal dissemination does not reduce survival in patients treated by cytoreductive surgery and perioperative intraperitoneal chemotherapy
González-Moreno S, Brun E, Sugarbaker PH

Prognostic indicators in peritoneal carcinomatosis from gastrointestinal cancer
Rhonda L Harmon and Paul H Sugarbaker

Are There Curative Options to Peritoneal Carcinomatosis?
Paul H. Sugarbaker, MD, FACS, FRCS

Elevated tumour markers prior to complete tumour removal in patients with pseudomyxoma peritonei predict early recurrence
Alexander-Sefre F, Chandrakumaran K, Banerjee S, Sexton R, Thomas JM, Moran B

Intraperitoneal hyperthermic chemotherapy for peritoneal surface malignancy: current status and future directions
Stewart JH 4th, Shen P, Levine EA

Studies Published - 2004
Pseudomyxoma peritonei usually originates from the appendix: a review of the evidence
Mukherjee A, Parvaiz A, Cecil TD, Moran BJ

Right hemicolectomy does not confer a survival advantage in patients with mucinous carcinoma of the appendix and peritoneal seeding
González-Moreno S, Sugarbaker PH

Clinically Aggressive Pseudomyxoma Peritonei: A Variant of a Histologically Indolent Process
Mohamed F, Gething S, Haiba M, Brun EA, Sugarbaker PH

Elevated Tumour Markers Prior to Complete Tumour Removal in Patients with Pseudomyxoma Peritonei Predict Early Recurrence
F. Alexander-Sefre, K. Chandrakumaran, S. Banerjee, R. Sexton, J. M. Thomas

Peritonectomy and intraperitoneal hyperthermic perfusion (IPHP): a strategy that has confirmed its efficacy in patients with pseudomyxoma peritonei
Deraco M, Baratti D, Inglese MG, Allaria B, Andreola S, Gavazzi C, Kusamura S

Incomplete cytoreduction in 174 patients with peritoneal carcinomatosis from appendiceal malignancy
Glehen O, Mohamed F, Sugarbaker PH

Cytoreductive surgery and intraperitoneal chemotherapy for pseudomyxoma peritonei
Güner Z, Schmidt U, Dahlke MH, Schlitt HJ, Klempnauer J, Piso P

Cytoreductive surgery with intraperitoneal chemohyperthermia for the treatment of pseudomyxoma peritonei: a prospective study
Loungnarath R, Causeret S, Bossard N, Faheez M, Sayag-Beaujard AC, Brigand C, Gilly F, Glehen O

Cytoreductive surgery combined with perioperative intraperitoneal chemotherapy for the management of peritoneal carcinomatosis from colorectal cancer: a multi-institutional study
Glehen O, Kwiatkowski F, Sugarbaker PH, Elias D, Levine EA, De Simone M, Barone R, Yonemura Y, Cavaliere F, Quenet F, Gutman M, Tentes AA, Lorimier G, Bernard JL, Bereder JM, Porcheron J, Gomez-Portilla A, Shen P, Deraco M, Rat P

Scientific research is extremely important in improving the treatment and curability of PMP, appendix cancer, and related peritoneal surface malignancies. Following are some of the pertinent research studies that have been published from 2004 to present.

* Research marked with an asterisk was partially or wholly funded by a PMPRF Research Grant.