About the Appendix Cancer PMP Research Foundation

Founded in 2008, the ACPMP Research Foundation was created by a community of individuals affected by appendix cancer, pseudomyxoma peritonei (PMP), and related peritoneal surface malignancies. The ACPMP Research Foundation is dedicated to supporting and funding promising research and education that moves us toward a cure for appendix cancer and PMP. The Foundation also endeavors to support the appendix cancer community of patients and their caregivers by providing the latest and most accurate information.

Program Summary

The ACPMP Research Foundation Changemaker Grant Program is intended to support scientific, clinical, or translational research studies—focused on appendix cancer or pseudomyxoma peritonei (PMP) of appendiceal origin—with the highest potential to ultimately impact patients or change our knowledge in appendiceal cancers to provide answers about this rare disease that will help to advance treatments for appendiceal cancer patients. Proposals are strongly encouraged in, but not limited, to the ACPMP Research Foundation Think Tank core research priority areas of: refining appendix tumor histology and histopathologic classification, defining the appendix tumor microenvironment, molecular characterization of appendix tumors and targets, conducting prospective investigations and trials, understanding appendix cancer on a population level, and developing disease-specific models and a model repository—as described in detail in Holowatyj et al. Nature Reviews Cancer. 2025. PubMed PMID: 39979656. 

Proposals aligned with this Award Program focus on appendiceal mucinous neoplasms, appendiceal adenocarcinomas (including signet ring cell adenocarcinoma and goblet cell adenocarcinoma), and/or pseudomyxoma peritonei of appendiceal origin; other cancer types are not eligible under this grant program. Applications will also be considered for their potential to lead to extramural funding applications (e.g., NIH, DoD, FDA, corporate sponsors), additional pre-clinical studies, and clinical trials.

The ACPMP Research Foundation Changemaker Grant provides $150,000 for direct costs associated with the proposed research project. Indirect costs are not allowed under this mechanism.

Eligibility Criteria

Applicants must hold a doctoral degree (e.g., PhD, MD, MD/PhD or equivalent) in a related field and must work at a medical, academic, or research institution. Full-time faculty members with an appointment at the rank of Assistant Professor or higher are eligible to submit one proposal per application cycle to the Changemaker Grant.

Individuals who currently have an active ACPMP Research Foundation Grant Award awarded under ACPMP’s Catalyst Research Grant Program are not eligible to apply.

Grant Application Deadline/Timeline

Full Application Deadline: September 1, 2025, at 5:00 p.m. EST 

Review of Applications: October/November 2025

Award Notification: November 2025

Start of Grant Term: December 1, 2025

Changemaker Grant Instructions

All applicants are required to complete an online grant submission by the application deadline using the ProposalCentral website.

Applicants are required to enter information directly into the ProposalCentral online submission platform as well as upload all necessary documents. These instructions outline details regarding information to be entered on the submission platform as well as required materials for upload.

Inquiries about the ACPMP Research Foundation Grant Program guidelines, eligibility, requirements, and application materials may be directed to the ACPMP Research Foundation at info@acpmp.org.

Applications will not be accepted in any other format. Late applications will not be accepted.

ProposalCentral Account Information:

NEW USERS with ProposalCentral: Select “Need an Account” and follow the prompts to complete the account registration process. After logging in, complete the ‘Professional Profile’ before beginning an application.

REGISTERED USERS with ProposalCentral: Log in to the site with your Username/Password. If you cannot remember your login details, select the “Forgot Your Password?” link and follow the prompts to reset your login information.

To begin an ACPMP Research Foundation Changemaker Grant Application: In ProposalCentral, select the “Grant Opportunities” tab/page. Find the “ACPMP Research Foundation Changemaker Grant” program and click the “Apply Now” button in the Apply column. Or use this direct link.

Any difficulties with registration, log in, or creating your Changemaker Grant Application can be directed to ProposalCentral Customer Support at pcsupport@altum.com or via phone at (800) 875-2562 (U.S. & Canada, Toll-Free) and +1-703-964-5840 (Direct Dial International).