BY Cynthia DeMarco | Published April 03, 2026 on mdanderson.org Medically Reviewed | Last reviewed by Beth Helmink, M.D., Ph.D., and John Paul Shen, M.D., on April 03, 2026 Until about 15 years ago, appendix cancer was often lumped together with colon cancer. That’s because the appendix is technically part of the colon. Today, though, doctors recognize appendix cancer as its own separate disease, with distinct genetic drivers at the molecular level that differ from those of colorectal cancers....